Born in San Francisco, California, Siguenza claimed in a 2006 interview that the nickname “Domino” came from his friends in high school: I got the name in high school. There is no meaning other than that it is associated with my first initial to my name Damian.”
Domino began his music career as a rapper, but by 1989-90 had switched almost exclusively to beat making, following the purchase of a Casio FZ 10M sampler.By the time he joined the Hieroglyphics in the mid-1990s, Domino concentrated solely on beat making and production.